2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-U00322
    5-HT3 antagonist 3 120635-47-4
    5-HT3 antagonist 3 (Compound 15b) is a high-affinity 5-HT3 receptor antagonist. 5-HT3 antagonist 3 binds to 5-HT3 receptors in rat brain cortical membranes with Ki of 0.25 nM.
    5-HT3 antagonist 3
  • HY-U00327
    Prenyl-IN-1 360561-53-1
    Prenyl-IN-1 is a protein prenylation inhibitor, especially a geranylgeranyltransferase (GGT) or a farnesyltransferase (FT) inhibitor, exhibiting potent activity against oxidative stress, and particularly in the treatment of Parkinson's Disease.
    Prenyl-IN-1
  • HY-U00334
    LH secretion antagonist 1 88531-67-3
    LH secretion antagonist 1 is an antagonist of luteinising hormone secretion, and may be used as an analgesic. LH secretion antagonist 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    LH secretion antagonist 1
  • HY-U00341
    ST4206 1246018-36-9
    ST4206 is a potent and orally active adenosine A2A receptor antagonist, with Kis of 12 nM and 197 nM for adenosine A2A receptor and adenosine A1 receptor, respectively. ST4206 has the potential for Parkinson׳s disease research.
    ST4206
  • HY-101831
    Heterocyclyl carbamate derivative 1 168830-01-1
    Heterocyclyl carbamate derivative 1 is a heterocyclyl carbamate derivative that may be used for the research of inflammatory and neurological diseases.
    Heterocyclyl carbamate derivative 1
  • HY-15085A
    (Z)-MDL 105519 179105-67-0
    (Z)-MDL 105519 is the inactive isoform of MDL 105519.
    (Z)-MDL 105519
  • HY-19282A
    (5R)-BW-4030W92 189013-61-4
    (5R)-BW-4030W92 is the R enantiomer of BW-4030W92. BW-4030W92 is a non-selective, voltage-, and use-dependent sodium channel antagonist.
    (5R)-BW-4030W92
  • HY-U00086
    Darodipine 72803-02-2
    Darodipine (PY 108-068, PY-108068) is a potent calcium channel antagonist.
    Darodipine
  • HY-U00102
    Suclofenide 30279-49-3
    Suclofenide (Neosulfalepsine; PB385) is an anticonvulsant that affects GABA metabolism.
    Suclofenide
  • HY-U00109
    Piridocaine hydrochloride 6099-95-2
    Piridocaine hydrochloride (Lucaine hydrochloride) is a piperidyl propanol ester of orthoaminobenzoic acid.
    Piridocaine hydrochloride
  • HY-U00114
    ZSET-845 324077-62-5
    ZSET-845 is a cognitive enhancer which enhances choline acetyltransferase activity in the hippocampus in the rat.
    ZSET-845
  • HY-U00126
    5HT6-ligand-1 1038988-11-2
    5HT6-ligand-1 is a potent 5-HT6 receptor ligand with a Ki of 1.43 nM.
    5HT6-ligand-1
  • HY-U00127
    Pyridazinediones-derivative-1 147493-44-5
    Pyridazinediones-derivative-1 has potential in treating neurodegenerative disorders. It shows an ED50 of 2.1 μM for inhibiting glutamate-induced contractions of isolated guineapig ileum.
    Pyridazinediones-derivative-1
  • HY-U00139
    Cyclodrine hydrochloride 78853-39-1
    Cyclodrine hydrochloride is a cholinergic (muscarinic, nicotinic) (mAChR and nAChR) receptor antagonist.
    Cyclodrine hydrochloride
  • HY-U00162
    SZ1676 159325-23-2
    SZ1676 is a derivative of SZ1677, which is a neuromuscular blocking agent.
    SZ1676
  • HY-U00180
    KF21213 155271-17-3
    KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors. KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM).
    KF21213
  • HY-U00189
    Sch412348 377727-26-9
    Sch412348 is a potent competitive antagonist of the human adenosine A2A receptor (Ki=0.6 nM) and has >1000-fold selectivity over all other adenosine receptors.
    Sch412348
  • HY-U00192
    CGP11952 64078-09-7
    CGP11952 is a triazolyl-Benzaphenon resembling the benzodiazepines in its pharmacological action. CGP11952 is an experimental benzodiazepine derivative.
    CGP11952
  • HY-U00195
    Piperylone 2531-04-6
    Piperylone can be used as an antispasmodic.
    Piperylone
  • HY-U00199
    Norzopiclone 59878-63-6
    Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.
    Norzopiclone
Cat. No. Product Name / Synonyms Application Reactivity